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Downing Street has appointed a new National Security Adviser days before Lord David Frost was due to start.

The chief Brexit negotiator was meant to take up the post on Monday, but will now be replaced by the Ministry of Defence’s Sir Stephen Lovegrove.

No 10 faced criticism over Lord Frost’s appointment in June last year, with former PM Theresa May saying he had “no proven expertise” in the area. Now he will be the PM’s representative on Brexit and International Policy.

A statement from Boris Johnson did not explain why Lord Frost was changing roles. But the prime minister said he was “thrilled” Lord Frost had accepted the new post, and that Sir Stephen would bring “a wealth of experience from across Whitehall and in national security”.

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Police have seized thousands of computers running one of the most dangerous hacking networks worldwide.

The Emotet network obtains access to victims’ computers, via malicious email attachments, then sells it to criminals who install more dangerous malware.

Police from the UK, EU, US and Canada worked together to “disrupt” Emotet.

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US security chiefs have warned of a heightened threat of domestic terrorism from people unhappy with the outcome of the November election.

The Department of Homeland Security said the 6 January attack on the US Capitol by Trump supporters may have emboldened some extremists.

In an advisory it warned of a threat from “individuals frustrated with the exercise of governmental authority”. But it added that there was no information on a specific plot.

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Production of the Oxford-AstraZeneca Covid-19 vaccine has been suspended at a plant in Wales after it received a suspicious package.

The Wockhardt UK plant was evacuated and a bomb disposal unit seen at the jab producer’s site at Wrexham Industrial Estate in Holt on Wednesday.

Wockhardt said it still aimed to stick to the “previously approved production schedule”. Downing Street said it is being regularly updated on the incident.

Wales’ First Minister Mark Drakeford said he was working with police and the military to find out more. Police said a cordon had been put in place near the Wockhardt plant and the public have been asked to keep away. There are no reports of any injuries.

In a statement Wockhardt UK said: “Production at the Wockhardt site is currently on hold while the situation is resolved, because the safety of our staff is paramount.

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Multiple people have been wounded – some of them seriously – in a knife attack on a train station in Frankfurt.

The attack occurred around 9am in the central German city before police overpowered and arrested the attacker.

Three people were seriously injured in the attack, local newspaper Frankfurter Allgemeine reported, though police added no injuries were life-threatening. Witnesses told the newspaper that the man seemed to be under the influence of drugs and appeared to chose his victims at random.

A police statement posted on Twitter said: ‘Frankfurt train district: One person was reported who is alleged to have injured several other people. They were arrested.

The exact circumstances of the crime are currently the subject of the investigation. There is no longer any danger. More information will follow.